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satisfied with the results of my first time eating kratom by itself, i decided that if it really is a mu receptor agonist, it should work great in combination with other opioids. so, the following night, i ate about 1. 8 grams of the kratom resin followed by 15 mg of hydrocodone. kratom certainly does have cns depressant effects. anyway, you should be fine mixing kratom and hydrocodone, and in a low dose it should boost it well enough without ' over- riding' it so to speak. of course going overboard with either is going be a bad idea, but if you take it slow and keep safe it low i don' t see why you would have any serious issues.